RAF Typhoon FGR4s have conducted a mission with French aircraft in a combined operation targeting an subterranean weapons facility in Syrian territory used by the IS group, per a report from the British defence ministry.
The site, located using reconnaissance, was believed to be containing munitions and bombs, the announcement noted, and was located in hills just to the north of Palmyra in the heart of Syria.
"Our aircraft utilized Paveway IV guided bombs to hit a series of approach shafts providing entry to the site... preliminary assessments indicate the objective was successfully hit," officials stated.
There was no indication of any harm to civilians in the strike on Saturday evening and all the aircraft returned to base without incident, the MoD added.
The Typhoon FGR4s were assisted by a Voyager aerial refuelling aircraft.
Daesh - alternatively referred to as ISIS - established militant control over parts of Syria and Iraq until 2019.
"This strike shows the UK's leading role, and resolve to operate in unison with our partners, to eliminate any resurgence of the terrorist group and their harmful and extremist ideologies in the area," Britain's Defence Chief John Healey remarked.
British military aircraft have conducted surveillance missions over Syrian airspace to "forestall any efforts to regroup" of the group subsequent to its routing at the Baghuz confrontation in 2019, the ministry said.
"I want to thank all the members of our armed forces involved in this operation for their expertise and their valour," he added. "Including them were numerous UK service members deployed over Christmas and New Year. This action, to take out terrorist threats who pose a risk to our security, shows how our armed forces are prepared to act, all year round, keeping Britain secure within its borders and strong abroad."
In December, the US military carried out what it called a "massive strike" on IS targets in the country, after an assault claimed the lives of two US troops and a civilian interpreter in the Palmyra area.
The UN reports Islamic State still boasts an estimated 5,000 to 7,000 militants in Iraq and Syria.